depression

How Do Ketamine Infusions Help Fibromyalgia?

How Do Ketamine Infusions Help Fibromyalgia?

Fibromyalgia is a leading cause of chronic pain affecting millions of Americans every day. Researchers hypothesize that central sensitization is the primary mechanism involved, but there are many other factors including genetics, immunological, psychological, and hormones that influence the development of fibromyalgia. Central sentization refers to a process called “wind-up” where the central nervous system gets regulated into a persistent state of high reactivity.  This persistent or wound up state of reactivity lowers the threshold for what causes pain and can create extreme pain even with minimal stimulus.  This phenomena is believed to be related to neuroplasticity which is mediated by the N-Methyl-D-aspartate (NMDA) receptors located in the spinal cord.

So how exactly do ketamine infusions help in fibromyalgia?

Ketamine’s most immediate mechanism of action is to block NMDA receptors.  It is the most potent clinically available NMDA receptor antagonist today.  By blocking the activity of the NMDA receptor, ketamine seems to reset the altered pain receptors that have become hypersensitized in patients with fibromyalgia.  

What Does A Ketamine Infusion Feel Like?

What Does A Ketamine Infusion Feel Like?

Ketamine infusions are becoming increasingly popular due to the fact they are can potentially rapidly treat anxiety, pain disorders, and treatment-resistant depression. You may be curious about what the experience of ketamine infusion will be like, especially since there is a lot of confusing and misleading information out on the internet. Well, we got you covered!!

What does a ketamine infusion feel like? Depending on how much ketamine and for how long you receive the infusion, you can experience anything from being more aware of how your body feels, quieting of the mind, and filled with feelings of love and gratitude all the way to feeling connecting to the Universe/God, death of your ego, and reliving past experiences.

5 Things You Need to Know About Intranasal Esketamine for Depression

5 Things You Need to Know About Intranasal Esketamine for Depression

Ketamine is made up of two enantiomers, one is called (R)-ketamine and the other is (S)-ketamine, also known as esketamine. All chemicals have two mirror images and when combined, it is called the racemic mixture. The generic version of ketamine contains both (R) and (S)-ketamine and has been approved by the FDA for use as a dissociative anesthetic agent since 1970.  

Standard & High Dose Ketamine Infusions in Treatment-Resistant Depression

Standard & High Dose Ketamine Infusions in Treatment-Resistant Depression

There is a growing body of clinical evidence that has shown how ketamine works to produce antidepressant effects in those with treatment-resistant depression (TRD). These studies have used a common subanesthetic dose of 0.5 mg/kg over a period of 40 minutes when administered through an IV. An outpatient study from 2018, published in Molecular Psychiatry, recently added onto this body of research in order to find the optimal dose for antidepressant effects in those with TRD. They found that single IV doses of ketamine of 0.5 mg/kg and 1 mg/kg proved to be more effective than an active placebo in reducing depression over a 3-day period.

Open Letter to Health Insurance Companies For Ketamine Treatments

Open Letter to Health Insurance Companies For Ketamine Treatments

Dear Health Insurance Company Representative,

Thank you for being a part of the system that helps to reduce the cost of health care for me and my patients.  I appreciate your commitment to collaborating and serving patients by covering the charges from unexpected healthcare fees.  Because of your services it allows for greater coverage to a large group of people for disease prevention, improving health, and fully living life.

Teaching an Old Drug New Tricks: Ketamine and Depression

Teaching an Old Drug New Tricks: Ketamine and Depression

This piece was published first on BreastCancer-News.com.  For more information about the author, Nancy Brier, click here. 

“No fresh flowers,” my doctor said. “Avoid salad. No uncooked food. And don’t bring visitors home.”

Treatment for breast cancer took the better part of a year, and a lot of that time, I spent alone. No wonder cancer sometimes comes with depression.

Ketamine For Teenagers With Depression

Ketamine For Teenagers With Depression

Major depressive disorder affects nearly one in four teenagers. Some characteristics of this disorder include irritability, fatigue, and low self-esteem. A major concern for this group in particular is suicide, especially since suicide is the third leading cause of death amongst teenagers. With traditional antidepressants, SSRIs, taking weeks to months to be effective and with over 40% of teenagers being non-responsive to traditional treatments, ketamine therapy may be a fast-acting treatment alternative.

6 Tips on Avoiding Ketamine Infusions

6 Tips on Avoiding Ketamine Infusions

You don’t have the time nor money to get infusions, or perhaps you are not ready...whatever your reason is, we get it.  As much as we love educating about ketamine and providing ketamine infusions, we’d love a world so healthy that we wouldn’t need to be in business.

However, the reality is there are a lot of people hurting, and we are honored to help them. But back to you all who aren’t ready or don’t ever want to find themselves in a ketamine clinic - here are 6 strategies to help you avoid getting a ketamine infusions:

Ketamine in Bipolar Disorder

Ketamine in Bipolar Disorder

Bipolar disorder will affect 4.4% of U.S. adults at some point in their lives. It can cause dramatic shifts in the mood, energy, activity, impacting a person’s ability to live fully. One of the symptoms of bipolar disorder is anhedonia, which is the loss of ability to seek pleasure. Effective treatments for anhedonia have traditionally been lacking, but fortunately, recent research suggests that ketamine can help.

A Brief History of Ketamine

A Brief History of Ketamine

The unique story of ketamine began in 1956 with the synthesis of the drug, phencyclidine. Found to be a remarkable anesthetic for monkeys, phencyclidine was then used on humans after numerous animal testings. Unfortunately, the side effects that researchers observed in some patients were concerning. Instead of waking peacefully from anesthesia, some patients experienced acute emergence delirium lasting hours after their operation was over. They described feeling sensory deprived and the loss of sensations in their limbs. Further studies concluded that phencyclidine produced a sensory deprivation syndrome.

14 Insights from the American Society of Ketamine Physicians’ Inaugural Conference 2018

14 Insights from the American Society of Ketamine Physicians’ Inaugural Conference 2018

The key to providing outstanding service to our patients is to keep educated and up-to-date. This month, we got to do so at the inaugural conference of the American Society of Ketamine Physicians (ASKP) in Austin, Texas.

We learned a massive amount from leaders in the field of ketamine research and treatment at the conference. While we want to share it all, we kept it simple and are sharing 14 insights from this conference with you!

3 Must Read Scientific Articles About Depression and Ketamine

3 Must Read Scientific Articles About Depression and Ketamine

Want to know more about how ketamine works? Especially curious about how it transforms the lives of those with depression, anxiety, and pain?  Love science?  A google or PubMed search will give you numerous articles on this topic.  At Reset Ketamine, we are big readers and lovers of learning so we found three articles you should check out regarding depression and ketamine...especially if you are science nerds like us! 

Ketamine Infusion Protocol: Twice a Week or Three Times a Week?

Ketamine Infusion Protocol: Twice a Week or Three Times a Week?

Ketamine infusions are at the frontier of treating depression, anxiety, PTSD, OCD, and pain disorders. And just like the pioneers of the Wild West, ketamine physicians are also trailblazers. Ketamine infusionists create their protocols based on studies and the responses of their patients to treatment. Since ketamine is still a relatively new treatment, researchers are still investigating the optimal dose and frequency.

How Ketamine Makes Your Brain “Re-Grow”

How Ketamine Makes Your Brain “Re-Grow”

Imagine a lush green forest, filled with many trees with numerous branches.  Now, imagine the opposite. The same trees, but instead brown and with branches falling off. These trees are now dying out. This forest is now sparse due to repeated fires, harsh weather, and pollution. The forest is functioning below what it could, and producing less oxygen and food for the creatures it protects.